There is a paucity of research evaluating the feasibility and potential impact of exercise in patients diagnosed with rare and less common cancers. Aims: To evaluate the effectiveness of an exercise program administered in a community-based setting among patients with rare and less common cancers. Methods: 127 patients participated (67% female; age 59±14 years; BMI 25±5 kg.m-2; 2.4±3.3 years since diagnosis). Participants had been diagnosed with one of ~25 different types of rare and less common cancers, predominately ovarian (15%), leukaemia (13%) and brain (10%). Between 2011-2014 participants self-enrolled in a 3-month community-based exercise program involving aerobic and resistance exercise supervised by accredited exercise physiologists across 13 fitness centres in metropolitan and regional WA. Assessments were conducted at baseline and post-intervention with questionnaires also administered at 6 months follow-up. Results: 75 participants (59%) completed the exercise program attending 18±4 out of a possible 24 sessions (75% attendance). Participants who withdrew, predominately due to being too unwell to continue (29%) and undergoing additional treatment (12%), completed 7±6 exercise sessions. No serious adverse events occurred during the exercise sessions. Significant (p≤0.05) improvements were observed baseline to post-intervention in physical function (400m walk 8% [-22s, 95%CI:-15 to -30s]; repeated chair rise 18% [-2.5s, 95%CI:-1.7 to -3.3]; strength 20% [15kg, 95%CI:9–21kg]; dynamic balance 18% [-3.9s, 95%CI:-1.9 to -5.8s]), various domains of quality of life (SF-36 4-13% [2.0–5.6 NBS, 95%CI:0.1–7.6]) and estimated monthly medical expenditure (SF-6D utility index 13% [$57, 95%CI:$15–98]). There was a trend towards improved fatigue (FACIT-F; p=0.1) and no difference in psychological distress (BSI-18). 47 participants (37%) completed the 6-month follow-up questionnaires. Significant improvements remained in quality of life (SF-36 6-11% [2.7–4.3 NBS, 95%CI:0.1–7.2]). Conclusions: A community-based exercise program resulted in significant and sustained improvements in the wellbeing of patients with rare and less common cancers.